IV-11. “Preliminary Study for Multi-regional Clinical Researches/Trials in Asia” (H27 FY2015)

  • Project Leader : Banno Haruhiko (Nagoya University, PhD Professional Office)
  • Collaborators : Hasegawa Yoshinori (Nagoya University, Center for Advanced Medicine and Clinical Research)
  • : Kasuya Hideki (Nagoya University, Graduate School of Medicine Office of International Affairs)
  • : Toyama Ayako (Kyoto University, Center for Southeast Asian Studies)
  • : Nakanishi Yoshihiro (Kyoto University, Center for Southeast Asian Studies)

Outline of Research

We will develop strategies and an action plan for multi-regional clinical studies and clinical trials between Southeast Asian countries and Japan. For this purpose, effective collaboration methods will be discussed by Thai and Japanese researchers. Our future goals include building an international study consortium among those countries. Both field researches in Southeast Asian countries and collaboration framework development in Japan are needed with valuable inputs by researchers at the Center for Southeast Asian Studies (CSEAS). Through this preliminary study, we will identify obstacles and create a roadmap for future collaboration in the field of neurological diseases between Southeast Asian countries and Japan. We will start with Thailand for its high clinical level, number of Japanese in the country, and the people’s attitude towards Japan.


In Japan, “drug lag” problem still exists and many Japanese patients cannot use up-to-date pharmaceuticals. Drug lag is a term that refers to the elapsed time between approval of a drug of foreign origin in other countries and in Japan. Additionally, Asian clinical studies are becoming increasingly important because pharmacogenetically the Japanese race has different background from the Caucasian race. Thus Asian consortium for clinical studies and clinical trials are indispensable in the future.

As we can see in amyotrophic lateral sclerosis (ALS), many neurological diseases are rare in number, but are not treatable. Therapy development is awaited for these diseases. Multi-regional study including gene analyses from multiple ethnic groups and international clinical trials recruiting many patients from many countries are a future direction to investigate disease mechanisms and to find a cure for these untreatable diseases. This project will also contribute Japanese presence in international scientific community.

Grand Rounds at Mahidol University Ramathibodi Hospital

JSPS Bangkok Center